The HudsonAlpha Clinical Services Lab Team

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Shawn Levy, PhD, Executive Director

Shawn Levy, PhD, serves as executive director of the HudsonAlpha Clinical Services Lab. He also is the founding director of the Genomic Services Lab at the HudsonAlpha Institute for Biotechnology, a nonprofit research institute in Huntsville, Alabama. Levy joined the Institute in 2009 and launched the HudsonAlpha Clinical Services Lab in 2014. Before moving to Huntsville, Levy served as assistant professor in biomedical informatics and molecular physiology and biophysics on the faculty at Vanderbilt University Medical Center in Nashville and was the founding director of the Vanderbilt Microarray Shared Resource. He is also adjunct faculty in the department of genetics and department of epidemiology at the University of Alabama at Birmingham and serves as an ad hoc reviewer for more than a dozen scientific journals.

Elaine Lyon, PhD, FACMG  Clinical Lab Director

Elaine Lyon, PhD, FACMG, comes from the University of Utah, where she served as medical director for molecular genetics, genomics and pharmacogenetics at the Associated Regional and University Pathologists (ARUP) Laboratories. At ARUP, she designed and validated laboratory assays for clinical use, including genomic sequencing. During her tenure, Lyon helped established four laboratory sections at ARUP: Molecular Genetics, Fragment Analysis, Genetics Sequencing and Genomics. She also held a faculty position at the University of Utah School of Medicine as professor of pathology.

Lyon received her PhD in medical genetics from the University of Alabama at Birmingham (UAB), and completed a fellowship in clinical molecular genetics at the University of Utah. She has served as president of the Association for Molecular Pathology and led the organization’s Task Force for the Framework for the Evidence Needed to Demonstrate (FEND) Clinical Utility. Lyon is also a member of the board of the American College of Medical Genetics and Genomics. Lyon brings more than 20 years of clinical genomics experience to the institute. Her national and international efforts have promoted appropriate molecular genetic clinical testing.

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David-Bick

David Bick, MD Assistant Lab Director

David Bick, MD, is the chief medical officer and faculty investigator at the HudsonAlpha Institute for Biotechnology, the Medical Director of The Smith Family Clinic for Genomic Medicine and assistant laboratory director of the HudsonAlpha Clinical Services Lab, LLC. He comes to HudsonAlpha Clinical Services Lab from the Medical College of Wisconsin (MCW) where he was professor in the department of pediatrics and the department of obstetrics and gynecology. At MCW, he was the director of the Clinical Sequencing Laboratory at Medical College of Wisconsin, director of the Advanced Genomics Laboratory at Children’s Hospital of Wisconsin, medical director of the Genetics Clinic at Children’s Hospital of Wisconsin, and chief of the division of genetics in the department of pediatrics at MCW.

Bick received his medical degree from George Washington University School of Medicine in 1981 and completed his residency in pediatrics at Yale-New Haven Hospital in New Haven, Conn. At the Yale University School of Medicine, Bick completed a fellowship in human genetics and pediatrics in 1986, followed by a postdoctoral research fellowship in human genetics in 1987. Bick is board-certified in pediatrics, clinical genetics and clinical molecular genetics. He is a leader in the field of genomic medicine and has published numerous peer-reviewed articles, chapters, and reviews. Bick’s laboratories at MCW and Children’s Hospital of Wisconsin were the first in the world to offer whole genome sequencing as a clinical test.

Liz Worthey, PhD Assistant Lab Director for Informatics

Liz Worthey, PhD, joined the CSL in 2015 as assistant lab director for informatics. She also is a faculty investigator and director of informatics and software development at the HudsonAlpha Institute for Biotechnology in Huntsville, Ala. Dr. Worthey received her Ph.D. in Genetics from the University of London in 2003 and completed her postdoctoral fellowship at the Seattle Biomedical Research Institute at the University of Washington, working on both Eukaryotic Genomics and other high throughput “Omics” projects. In 2008, after working as a Project Manager for Merck & Co., Worthey joined the Medical College of Wisconsin (MCW) as Senior Research Scientist and became an Assistant Professor of Pediatric Genomics in 2010. Worthey became Director of Genomic Informatics for the Human and Molecular Genetics Center at MCW in 2012. She also holds an Adjunct Assistant Professorship in the Computer Science Department at the University of Wisconsin – Milwaukee.

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Brett Sundlof

Clinical Lab Supervisor

Brett Sundlof is clinical lab supervisor of the HudsonAlpha Clinical Services Lab. Brett previously worked at Sequenom as supervisor of sequencing modules supporting the MaterniT21 diagnostic test, utilizing Illumina-based NGS of cell-free fetal nucleic acid, and analysis of the relative amount of trisomy 21, 18, 13. Prior to that, Sundlof worked at LabCorp in molecular genetics and oncology laboratories, where he analyzed patient samples for inherited genetic diseases and gene mutations. Sundlof graduated with B.S. in health science from the State University of New York, SUNY Brockport.

Camille Birch

Clinical Analyst

Camille Birch, PhD is a biomedical engineer and biophysicist. She joined the Software Development and Informatics group led by Dr. Liz Worthey in January 2016 and contributes to the CSL as a clinical analyst. Dr. Birch has published works in protein interactions and the effects of sex hormones on disease outcomes. She received her PhD from the University of Arizona in Biomedical Engineering in 2015.

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Donna Brown

Clinical Analyst

Donna Brown, MSc, is a clinical analyst working to find genetic variants in the genomes of patients that lead to a diagnosis. She joined the CSL and the Software, Development, and Informatics group headed by Dr. Liz Worthey, in January 2016. Her many years of experience have led to publications in the fields of genomics and disease mapping, particularly in the field of renal failure. She received her MSc in biological sciences from the University of Alabama – Huntsville, in 1991.

Melissa Wilk

Clinical Genomic Variant Scientist

Melissa completed her PhD in Cell and Developmental Biology at the Medical College of Wisconsin. She continued her learning experience as a post-doctoral fellow, working with Drs. Howard Jacob and Elizabeth Worthey at HudsonAlpha Institute for Biotechnology. Later, she became the Lab Supervisor for Software Development and Informatics, under the direction of Dr. Worthey. During her time at HudsonAlpha, Melissa has been involved in a variety of projects, including diagnosis of rare disease through the Undiagnosed Diseases Network, identification of genetic modifiers in cystic fibrosis, and development of software for genomic analysis and interpretation.

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James Holt (Matt)

Clinical Data Scientist

Matthew completed his PhD in Computer Science at the University of North Carolina-Chapel Hill, where he developed novel bioinformatics algorithms for processing, storing, and querying sequencing data from Collaborative Cross mice.  He continued his studies as a post-doctoral fellow in the Software Development and Informatics group at HudsonAlpha, focusing on development and application of algorithms and methods for analyzing clinical sequencing data in the context of rare disease patients.  While at HudsonAlpha, he has developed pipelines for identifying pathogenic structural variants, algorithms for identifying diploid-triploid mixoploidy, and machine learning methods for prioritizing clinical variants.

Adriana Stout

Business Coordinator

Adriana Stout is a Lab Business Coordinator in the HudsonAlpha Clinical Services Laboratory. During her time at HudsonAlpha, Adriana has worked closely with several teams to help drive the mission and vision, contributing to their success in providing access to genomic data and analysis to physicians, healthcare, and patients to improve health. 

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Executive Board

Barbara Fisk

Jim Hudson

Danny Windham

Officers

Richard M. Myers, PhD

Pete Yanul